Multibranched-Based Fluorinated Materials: Tailor-Made Design of ¹⁹F-MRI Probes

ConspectusFuture medicine is primarily aiming at the development of novel approaches for an early diagnosis diseases and a personalized therapy patients. For achieving these objectives, key role played by medical imaging. Among available noninvasive imaging techniques, Fluorine-19 (19F) Magnetic Resonance Imaging (MRI) emerging as powerful quantitative detection modality clinical use both molecular cell tracking.The strength using 19F-MRI mainly related to lack endogenous organic fluorine in tissues, with no background, enabling visualization fluorinated tracers hot-spot images, adding secondary independent information anatomical features provided grayscale 1H-MRI. The main challenge application intrinsic reduced sensitivity MRI. To improve sensitivity, undoubtedly high field MRI scanner cryogenic radiofrequency probes advantageous, but there clear need developing increasingly effective tracers.The ideal tracer should bear many possible magnetically equivalent atoms show optimal magnetic resonance relaxivity properties (i.e., T1 T2), which enable acquisition time possibility apply fast methods. Moreover, it be biocompatible tendency bioaccumulate one drawbacks perfluorocarbons (PFCs), together their difficulty chemically modified functional groups. In fact, PFCs such perfluorooctyl bromide (PFOB), perfluoro-15-crown-5-ether (PFCE), linear perfluoropolyethers (PFPE) are currently most used preclinical studies, above-mentioned limitations. this regard, molecules bearing short branched chains gained lot attention number fluorines expected capability reducing bioaccumulation concerns. A valuable building block perfluoro-tert-butanol (PFTB), nine easy availability modification.In Account we will discuss challenges that has overcome increasing its use, highlighting on hand customized materials multimodal properties, other hand, importance ultrastructure final formulation biological response clearance). context, our group been focusing synthesis tracers, originator molecule called PERFECTA (from suPERFluorinatEdContrasT Agent), 36 equiv 19F atoms, showed not only relaxometry also very specific intense Raman signal. Thus, derivatives represent new family multiscale analysis, from whole body (19F-MRI) microscopic cellular/tissue level (Raman microscopy). We believe proposed PFTB strategy can strongly promote production additional functionalities, facilitating translation modality.